Assignatura

Biologia Molecular

  • codi 07603
  • curs 1
  • període Semestre 2
  • tipus FB
  • credits 8

Mòdul: Morfologia, estructura i funció del cos humà

Matèria: Biologia molecular: Fonaments de biologia

Llengua d'impartició principal: anglès

Professorat

Responsable

Dr. Josep CLOTET - jclotet@uic.es

Horari d'atenció

 

 

Contact us

Ask for informations or for an appointment, with either of us, at our following email addresses:

Dr. Jaume Reventós  (jreventos@ir.vhebron.net)

Dr. Andreas Doll (adoll@ir.vhebron.net)


( please do not use the UIC email addresses !!!!!!)

Presentació

 

During the last 40 years, molecular biology has gone through the most unbelievable and dramatic revolution by far much more important than any other scientific discipline.

Biology, and, as a consequence, medicine, have to be written, analyzed and studied again, or, in others words, reconceived by using the new tools, technologies and all the new knowledge brought by molecular and cellular biology as well as by biochemistry, physics, mathematics, etc.

 

Requisits previs

No procedeix

Objectius

 

Aims

The teaching of the molecular biology subject in the coming months has to provide to the student the basic knowledge, the tools and the mechanisms of thinking suitable to understand the molecular bases of disease, as well as all the technology necessary to practice medicine with the scientific method.

Competències

 

Competences

At the end of the semester, and having completed all the teaching sessions, students have to be able to:

Understand the bases of molecular biology and the techniques currently used in the diagnostic process.

Design strategies for diagnosing and studying diseases of molecular bases.

Understand the bases of gene transcription and its regulation, which are the essence of fisiology and disease.

Resultats d'aprenentatge

To obtain the suggested competences

Continguts

 



Tema 1  Topic 1: Presentation and general vision of molecular biology in medicine.

Professor: Jaume Reventós



Tema 2 Topic 2: The complexity of the human genome.

Professor: Jaume Reventós



Tema 3  Topic 4: Translational control and elucidation of the genetic code.

Professor: Andreas Doll



Tema 4 Topic 3: Controlling eukaryotic gene expression.

Professor: Jaume Reventós



Tema 5 Topic 5: Molecular genetic techniques and genomics.

Professor: Andreas Doll



Tema 6 Topic 6: Epigenetic controls or Lamarck wasn’t wrong.

Professor: Andreas Doll



Tema 7 Topic 7: DNA damage and diagnosis of genetic diseases.

Professor: Andreas Doll



Tema 8 Topic 8: Genomics: microarrays, SNPs and disease.

Professor: Andreas Doll



Tema 9 Topic 9: The introduction of foreign genes in cells, animals and plants: transgenesis.

Professor: Jaume Reventós



Tema 10 Topic 10: Working toward human gene therapy.

Professor: Jaume Reventós



Tema 11 Topic 11: Biotechnology.

Professor: Jaume Reventós



Tema 12 Topic 12: Proteins, proteomics as tools to investigate disease.

Professor: Andreas Doll



Tema 13 Topic 13: Molecular bases of cancer.

Professor: Jaume Reventós



Tema 14  Topic 14: Understanding molecular diagnosis and biomarkers in human disease.

Professor: Andreas Doll



Tema 15 

CM15, General review

Tema 16 Casos Clínics

Metodologia i activitats formatives

Modalitat totalment presencial a l'aula

Main classes or Classes magistrals (CM): Theoretical presentation of a particular topic by the teacher (2 hours including a 15 minute break).


Problem Based Learning (PBL) or Aprenentatge Basat en Problemes (ABP): Discussion of a specific problem by the students. The students will draw the methods, results and conclusions. The teacher will guide the whole discussion.


Clinical Cases or Casos Clínics (CC): Exposition of a clinical case known in advance. The students will raise questions and answers to resolve it. It will be prepared in small groups which will expose a power point presentation. The teacher will guide the whole process.


Practical work or Pràctiques (P): Experimental laboratory practical works of molecular biology techniques. Visit to the Vall d’Hebron Research Institute.


Virtual Teaching or Ensenyament virtual (EV): Teaching material available on line, that could be included in the partial and final tests.

Sistemes i criteris d'avaluació

Modalitat totalment presencial a l'aula

50% Partial test (Note: To pass this partial test, students need a score of 65% or more of correct answers. Total= 100 questions).

50% Final test (Practical work, 10 questions in the final test; and Clinical cases, 10 questions in the final test. Total 100 questions).

Note 1: up to a 30% of the questions in the tests do not necessarily would belong to the topics presented in the classes, but have to be in the recommended readings.

Note 2: in order to average all the partial evaluations, the score result of the final test has to be at least 5.

Note 3: both tests will be of multiple choice having 4 possible answer options. Correct answers will count +1 and errors -0.25.

Bibliografia i recursos

Molecular Cell Biology, Lodish et al. Sixth Edition 2008, W.H. Freeman and Company.

 

Període d'avaluació

E: data d'examen | R: data de revisió | 1: primera convocatòria | 2: segona convocatòria:

  • E1 05/06/2012 09:00h
  • E2 05/07/2012 09:00h

Material didàctic

      Materials
            Capítulo cancer del Lodish molecularcellbiologylodish5thedcancer.pdf 
            Capítulos relevantes del Lodish 5 para los temas CM 1-5 molecularcellbiologycapitulosrelevantes.pdf 
            Color Atlas of Genetics thiemecoloratlasofgenetics3ed.2007-eberhardpassarge.pdf 
      Webs d'interès
            An animated primer on the basics of DNA, genes, and heredity  http://www.dnaftb.org/ 
            DNA interactive http://www.dnai.org/index.htm 
            Your Genes Your Health - A Multimedia Guide to Genetic disorders http://www.ygyh.org/ 
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